New Gout Drugs
by joseph » Wed Oct 05, 2016 2:39 pm

Natural Gout Remedies - New Gout Drugs - Pegloticase Continues Its Hopeful Path

May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

Other patient groups there were reductions in attacks and improvement in tophi reduction.
Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

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This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

The world of natural gout remedies, uric acid's removal can be improved by making it more soluble.
This is achieved by drinking lots of water and by raising body pH levels in various ways.
We have used a mixture of seriousness and jokes in this composition on Uric Acid Level.
This is to liven the mood when reading about Uric Acid Level.
SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients.
The developing company has said that most were mild, moderate, or controllable.
But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.
Keeping to the point is very important when writing.
So we have to stuck to Excess Uric Acid, and have not wandered much from it to enhance understanding.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

Has Been Having a Decent Degree of Success

Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial. To err is human, to forgive is divine. So we would indeed deem you to be divine if you forgive us for any misunderstandings that may arise in this article on Uric Acid.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial.
It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase. Interesting is what we had aimed to make this article on Gout Drug. It is up to you to decide if we have succeeded in our mission!

Under normal circumstances, the purines you find in many foods are broken down into uric acid, and the body gets rid of it without any problems. However, alcorn state university gout, getting rid of this uric acid is problematic, and the result is painful crystals forming in the joints - leading to gout pain. When this happens, there are medications that can help with the pain, but one of the best things a person can do it to is to find low purine foods and make them a major part of their diet. This can offer much-needed relief for most.

Looking for some inspiration?
The Gout Haters Cookbooks series by Jodi Schneiter are just what you need.
Jodi has written three cookbooks that focus on creating delicious meals suitable for all the family that fit in with a low purine diet.
Click on the link below for more information:

There are some general directions for a low purine diet, but always listen to your doctor's advice in addition to this information. A low purine diet is going to contain almost fifty percent carbohydrates each day, and no more than thirty percent of the diet each day should be made up of fats. The rest should be healthy and lower purine protein sources. Drinks that are normally not allowed on many special diets are actually encouraged. These include soda and coffee. The reason being as that they act as directics, helping your body to flush out the excess uric acid. It's important to drink plenty of water as well to keep your body well hydrated. Alcohol, however, in most forms is not something you should be drinking. :evil:

You may have a hard time finding new foods to eat at first, but after a while you will get used to reading labels and figuring out what works for you and what does not. Any special diet requires a little thought and work, and the low purine foods diet is no exception. After a while though, reading and deciphering items in the store by reading through the ingredients list will become second nature, and you will become accustomed to knowing how to build your own menu with little thought. Feeling better should be all the motivation you need. Enhancing your vocabulary is our intention with the writing of this article on Excess Uric Acid. We have used new and interesting words to achieve this.

When choosing your low purine foods, you can have some medium purine rated foods with them about once a day if it does not bother you. Those would include some meats like beef, pork, and possibly chicken. Some seafood choices are relatively safe as well. You should experiment to find what bothers you and what works out well. As long as you work at limiting the purines, you are going to feel much better each day. You might want to have lobster bisque on occasion, as long as you limit your portions, and don't have any other medium purine foods for the rest of the day. We have not included any imaginary or false information on Uric Acid here. Everything here is true and up to the mark! :shock:

When looking for low purine foods for your diet, you can find a great variety of things you can have that won't cause any issues with your gout.
If you love thick soups, you can have them as long as they are made with low fat milk.
Cheese and milk are fine, but again, they should be low in fat.
You can also enjoy things like gelatin and a great variety of fruits and fruit juices.
Most sweets are just fine, but remember to watch the calories if you are attempting to get your weight down.
You can also enjoy things like pasta, and peanut butter is okay for a treat.
Using our imagination has helped us create a wonderful article on Gout.
Being imaginative is indeed very important when writing about Gout!

Did you know that there are numerous natural gout treatments that have been shown to be effective in many natural health studies?

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There are thousands of benefits for drinking water, and a natural gout remedy is one of them. We were a bit tentative when embarking on this project on Foods Uric Acid. However, using the grit and determination we have, we have produced some fine reading material on Foods Uric Acid. :lol:

Why Gout is Naturally Treatable In most cases, to treat something, you look to see what causes the problem and eliminate the cause.

For instance, with high blood pressure you eliminate salts and watch your diet which will decrease plaque build up.
And the same thing goes with gout!
Forget the pain killers you use to treat your gout!
Finally, get a full nights sleep!
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Discover the step by step natural treatment at Natural Gout Treatments Website.

3. Apple Cider Vinegar- Apple cider vinegar both ingested and applied topically can help treat gout symptoms. In a glass, combine two teaspoons of apple cider vinegar with two teaspoons of raw honey and drink once daily. The vinegar will balance your pH levels to lower your uric acid levels. Topically, combine one cup of vinegar with 3 cups of water and soak your toe. Using the intuition I had on Cure Gout, I thought that writing this article would indeed be worth the trouble. Most of the relevant information about treatment of gout has been included here. :evil:

The Case of Gout, Uric Acid Crystals Between the Joints Cause of Gout

While you sleep (usually), the gout flare-ups are caused by settling uric acid between the joints in the big toe. Your bed sheets will often feel like a ton of bricks and the smallest amount of pressure will feel like you got your toe slammed in a door. An idle brain, is a devil's workshop they say. Using this ideology in mind, we ventured to write on Uric Acid, so that something productive would be achieved of our minds. :oops:

Fact, Gout Remedies Have Been Around for Thousands of Years

For instance, gout was once known as the disease of kings because so many kings complained about the arthritis of their big toe. And if you think about the royal disease, it is no wonder that kings had gout considering that gout is caused by fattening diets, alcohol consumption and is genetic.

Five 'Dordt college' Gout Treatments Treating Gout can be as simple as watching your diet, stop the gout by eating the right food supplements, neutralizing the uric acids, drinking the right fluids or even doing gout-free exercises. The truth about gout symptoms on what stage your gout is in. Here are five 'do it yourself' gout treatments. Writing something about Gout Symptoms seemed to be something illogical in the beginning. However, with the progress of matter, it seemed logical. Matter just started pouring in, to give you this finished product.

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With a combined 22 years of natural health expertise, Barton Publishing is the leader in natural health reports. Cure yourself with a Gout Remedy Report today! We had at first written a rough assignment on Gout Uric. Then after a few improvisions and enhancements here and there, we have ended up with this end product.

A Gout-Free Diet- Do you know what foods cause uric acid levels to shoot through the roof?
Do you know what foods contain purines (partially the cause of gout)?
You must use diet health tips to prevent flare-ups.
Our Gout Remedy Report gives you everything you need to know about foods and dieting with gout.
Opportunity knocks once.
So when we got the opportunity to write on Gout Diet, we did not let the opportunity slip from our hands, and got down to writing on Gout Diet.

2. Supplements- Many of our customers have found success in supplements. For instance, Vitamin C is the wonder vitamin. Because it lowers uric acid levels, vitamin C can be used for prevention as well as during an acute gout attack. During a gout attack, 1,000 mg per hour is helpful. For prevention, 500-3,000 mg daily would work. Coordinating matter regarding to Treating Gout took a lot of time. However, with the progress of time, we not only gathered more matter, we also learnt more about Treating Gout. :oops:

But Simple, Effective Natural Gout Treatments Aim to Decrease the Body's Uric Acid Levels

Thus, curing arthritis in the toe permanently. Here are some natural gout treatments taken from our gout remedy report. There has been a gradual introduction to the world of Gout Attack projected in this article. We had done this so that the actual meaning of the article will sink within you.

1.12 glasses of water- Believe it or not, water can greatly assist in the prevention and treatment of formation of uric acid crystals.
In addition, it can help your body to more effectively eliminate the crystals once they have formed.

Be Gout Free in Less Than 2 Hours If you live within 30 minutes of a store, then you can cure gout naturally in the next few hours with our Gout Remedy Report!

5. Vitamins- Did you know that gout sufferers typically are deficient in vitamins A, B5 and E? With that said, you could go out to your local health store and buy these vitamin supplements or you could buy 'miracle' gout fruit! This article will help you since it is a comprehensive study on Gout Treatments.